Folic acid supplementation in pregnant women with hepatitis B surface antigen improves infant hepatitis B surface antibody mediated by infant IL-4Article Published on 2023-05-282023-06-09 Journal: The British Journal of Nutrition [Category] B형 간염, [키워드] Folic acid Hepatitis B virus IL-4 immunisation Mediation effect. [DOI] 10.1017/S000711452200229X PMC 바로가기
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein주요 프로테아제 및 스파이크 단백질의 수용체 결합 도메인에 대한 분자 도킹 연구를 기반으로 천연 화합물을 COVID-19의 잠재적 치료제로 용도 변경Article Published on 2022-05-162022-09-11 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CLpro ACE2 active site acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin benfotiamine binding binding site Cell Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease docking drug Drug discovery enzyme Folic acid fursultiamine Host human Angiotensin-converting enzyme identify in silico inhibiting K417 life cycle main protease molecular docking molecular dynamics Molecular dynamics simulation potential therapeutic agent protease Protein R403 RBD receptor Receptor-binding domain receptor-binding domain. Replication repurposing residue Riboflavin S protein S-protein S-RBD Safe SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus Spike protein target the RBD the receptor-binding domain Vitamin vitamin B12 vitamins Y449 [DOI] 10.1007/s00894-022-05138-3 PMC 바로가기 [Article Type] Article
Prevalence of Micronutrient Deficiencies in Patients Hospitalized with COVID-19: An Observational Cohort StudyObservational Study Published on 2022-04-292022-10-05 Journal: Nutrients [Category] 임상, [키워드] 95% CI adjusted Admission age analyzed association B12 Clinical course Cohort composite endpoint coronavirus disease correlation correlation coefficient courses COVID-19 deficiencies deficiency eight Folic acid higher risk hospital hospital outcomes Hospitalized ICU in-hospital mortality intensive care IQR Logistic regression lower risk male Micronutrient micronutrients micronutrients. MOST older patient Patient Prevalence prevalent progression Research SARS-CoV-2 serum/plasma severe COVID-19 severe COVID-19 disease severe disease progression Treatment Vitamin vitamin A [DOI] 10.3390/nu14091862 PMC 바로가기 [Article Type] Observational Study
Association of the IL-6R gene polymorphic variant rs2228145(C>A) with IL-6 gene polymorphisms in a healthy cohort of Turkish population Research Published on 2022-04-012022-10-05 Journal: Genes and Immunity [Category] 바이오마커, 유전자 메커니즘, [키워드] age allele allele G allelic association Bilirubin BMI body mass index Cohort collected Comorbidity Concentration Diseases evaluated explained fasting insulin Folic acid Frequency Gender Globulin healthy hematological parameters hormone IL-6 IL-6R IL-6R gene individuals Laboratory laboratory data laboratory parameter Liver function test loci locus majority monocyte neutrophil Platelets polymorphic variant polymorphism renal rs2228145 SHBG significantly higher significantly lower subject uric acid variant Variation White blood cells [DOI] 10.1038/s41435-022-00167-7 [Article Type] Research
Food nutrients as inherent sources of immunomodulation during COVID-19 pandemicReview article Published on 2022-03-012022-10-05 Journal: LWT [Category] 임상, [키워드] absence acute respiratory syndrome affecting antibody B-cells boosting immunity caused clinical trial clinical trials Community component Compound coronavirus COVID-19 COVID-19 pandemic Defense dendritic cells doses Factor Folic acid food fortified fruits functional globe Host immune component Immune components immune system Immunity Infection inherent initial investigated knowledge Natural killer cells Neutrophils Novel coronavirus Nutrients pathogen Patient reduction in retrospective cohort study SARS-CoV-2 severity of COVID-19 shown Spread stress levels T-cell vaccination Vaccine viral infection [DOI] 10.1016/j.lwt.2022.113154 [Article Type] Review article
A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching AnalysisArticle Published on 2022-01-082022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Acetate Admission age Analysis Anticoagulants association ATC blood pressure candidate Case-control clinical trials Cohort Colchicine Comorbidity confounding variable coronavirus disease Coronavirus disease 2019 (COVID-19) Corticosteroids COVID-19 COVID-19 disease diagnosis of COVID-19 drug Final Folic acid fumarate help hospital hospitalisation hospitalised increase in Inhaled Interaction matching medication Mortality number of comorbidities Patient patients died previous medication propensity score matching analysis PSM reduction in retrospective risk factor score severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe COVID-19 disease Sex Spain survival underlying conditions was performed with COVID-19 [DOI] 10.3390/ph15010078 PMC 바로가기 [Article Type] Article
Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy스페인과 이탈리아에서 Covid-19 사망률의 위험 증가를 나타내는 기준선 약물 치료Observational Study Published on 2021-11-102022-08-31 Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료제, [키워드] analyzed Antithrombotic approach baseline Campania chronic cardiovascular Clinical practice Cohort Community condition conducted COVID-19 COVID-19 patient death demographic variable diuretics drug drugs Folic acid identify Increased increased risk Indicator individual Infection Italy likelihood logistic regression models medication medications Metabolic diseases minimum Mortality observational study occur pharmacological Pharmacy Potassium profile real-world data Region Result retrospective SARS-COV-2 infection Spain systemic inflammation the disease thrombosis vitamin B12 [DOI] 10.3390/ijerph182211786 PMC 바로가기 [Article Type] Observational Study
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models엽산 길항제 메토트렉세이트는 코로나바이러스 SARS-CoV-2의 복제를 감소시키고 세포 배양 모델에서 렘데시비르의 항바이러스 효능을 향상시킵니다Article Published on 2021-09-012022-09-11 Journal: Virus research [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] aberrant inflammatory response Aberrant inflammatory responses addition Antiviral antiviral activity antiviral agent antiviral efficacy benefit calu-3 cells Cancer therapy Cell culture Combination Concentration coronavirus coronavirus SARS-CoV-2 COVID-19 cultured cells decrease described dihydrofolate Dihydrofolate reductase diminishe dissemination distress drug Efficacy ENhance enzyme Enzymes Folic acid Folinic acid Frame host cell Immunosuppression impairment induce Infection inhibit inhibited Inosine Leucovorin limit mechanism methotrexate MTX nucleocapsid nucleotide nucleotides Organisms Perspective progeny protein synthesis purine Purine synthesis raise reduce reductions in released Remdesivir Replication replication of SARS-CoV-2 required rescued respiratory distress RNA RNA replication SARS-CoV-2 SARS-CoV-2 infections spike Spike. structural protein structural proteins synergistic synthesis tested therapeutic therapy Toxicity treating COVID-19 treating SARS-CoV-2 infection Vero Vero E6 virus virus replication virus RNA [DOI] 10.1016/j.virusres.2021.198469 PMC 바로가기 [Article Type] Article